Treatment of Calcium-Channel–Blocker Intoxication with Insulin Infusion
- 31 May 2001
- journal article
- letter
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 344 (22) , 1721-1722
- https://doi.org/10.1056/nejm200105313442215
Abstract
Overdose of calcium-channel blockers remains an important cause of fatal poisoning.1 Conventional therapy, consisting of intravenous fluids, calcium, dopamine, dobutamine, norepinephrine, and glucagon, often fails to improve hemodynamic function in intoxicated patients.2 Recent recommendations for treatment of intoxication with calcium-channel blockers include induction of hyperinsulinemia and euglycemia as adjunctive therapy.3 We report two cases of overdose of calcium-channel blockers in which a striking benefit was achieved with hyperinsulinemia–euglycemia therapy.Keywords
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