Gonadotroph Cell Adenomas of the Pituitary*

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Abstract
Introduction GONADOTROPH cell adenomas of the human pituitary gland were first appreciated to be a distinct entity as a result of a group of case reports in the mid-1970s (1–6). These reports provided evidence that the gonadotroph cell adenoma represented a different biological phenomenon than hyperplasia of the gonadotroph cells consequent to primary hypogonadism, which had been reported previously (7–11). As gonadotroph cell adenomas have been recognized more frequently and better studied during the last few years, certain clinical and hormonal characteristics have come to be appreciated that make this a recognizable pathophysiological and clinical entity.

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