IMMUNOBLASTIC LYMPHADENOPATHY - REPORT OF 2 CASES

  • 1 January 1976
    • journal article
    • research article
    • Vol. 100  (9) , 465-468
Abstract
Two patients who had immunoblastic lymphadenopathy with clinical symptoms of fever, anemia, hypergammaglobulinemia and enlarged lymph nodes were treated with chemotherapy. The lymph node biopsy specimens were originally interpreted as malignant processes because of severe immunoblastic and plasmacytic infiltration that practically obliterated the architecture of the lymph nodes. One patient recovered and was free of symptoms 5 yr after clinical onset of the disease. The 2nd patient died of massive gastrointestinal bleeding 6 wk after the onset of disease and 5 wk after administration of cytotoxic drug therapy. The cases illustrate the ineffectiveness and possible adverse effect of chemotherapy, and the importance of differentiation of immunoblastic lymphadenopathy from frankly malignant lymph node diseases.