Effect of Nicotinic Acid and Related Compounds on Incorporation of Mevalonic Acid into Cholesterol

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Abstract
Nicotinic acid and related compounds (0.1 to 5 mg/ml) have no significant effect on conversion of mevalonic acid to nonsaponifiable material by rat liver homogenates. Incorporation of acetate into nonsaponifiable material (largely cholesterol) decreases with increasing amounts of nicotinic acid. At 1 mg/ml of nicotinic acid a 34% average decrease in biosynthesis was observed. Results suggest that the locus of the nicotinic acid effect may be somewhere between acetate and mevalonate.

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