Association of centromeric heterochromatin with the nucleolus in mouse sertoli cells

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Abstract
In adult Sertoli cells of most strains of mice, all the centromeric heterochromatin is condensed in two chromocenters, one on each side of a single, large nucleolus. In a random‐bred Swiss OF‐1 strain, however, the nucleus has a different structural organization. Part of the heterochromatin is seen as chromocenters in contact with the nucleolus; the rest of it is dispersed in granules of unequal size in the nucleoplasm. Such an unusual spatial arrangement of heterochromatin in interphase nucleus cannot be explained either by a difference in the nucleolar organizing regions or by a polymorphism of the C‐banding of metaphase chromosomes.