Isolation and structure of the unusual Indian Ocean Cephalodiscusgilchristi components, cephalostatins 5 and 6
- 1 October 1989
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 67 (10) , 1509-1513
- https://doi.org/10.1139/v89-231
Abstract
The Indian Ocean (South African) marine worm Cephalodiscusgilchristi (Hemichordata phylum) has been found to contain a series of unusual disteroidal alkaloids, designated the cephalostatins, that possess exceptionally potent lymphocytic leukemia (murine P388) cell line inhibitory activity (to ED50 10−9 μg/mL). Two of the less prominent members with P388 ED50 10−3–10−2 μg/mL, cephalostatins 5 (2) and 6 (3), were isolated and assigned structures based on rigorous interpretation of two-dimensional 400-MHz 1H and 13C nuclear magnetic resonance. Keywords: cephalostatins 5 and 6, disteroidal alkaloids, lymphocytic leukemia, cytostatic, Cephalodiscusgilchristi.This publication has 2 references indexed in Scilit:
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