The Effect of 2-3 Dimercapto-Propanol (BAL) on Experimental Nickel Carbonyl Poisoning

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Abstract
Rats and rabbits were exposed to the inhalation of Ni carbonyl of known concns. The animals died of acute pulmonary edema within a few days or recovered to develop pulmonary fibrosis, max. at 3 mos. and gradually resolving. Only 5-10% of the inhaled Ni was found in the lungs. Ni is rapidly translocated in the body and is not firmly retained by the tissues. In rats BAL at a dose of 60-80 mg./kg. given therapeutically had little effect except at 1 level of Ni carbonyl where fewer rats survived. In rats BAL given prophylactically had some protective action against the lower doses of Ni carbonyl. In rabbits BAL given after exposure to Ni carbonyl, reduced the mortality rate and increased the survival time, but these effects were not sufficiently great to be significant with the number of animals employed.
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