Stage-specific immunogens ofHymenolepis nanain mice

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Abstract
Treatment with praziquantcl at the beginning of the lumen phase ofHymenolepis nanain mice showed conclusively that: (i) the mouse given eggs ofH. nanaproduces two separate immune responses against reinfection, one directed exclusively against the tissue phase of egg challenge (early response), the other against the lumen phase of cysticcrcoid challenge (late response); (ii) a tissue phase of egg inoculation is not necessary for initiating the late response but is necessary to provoke the early response; and (iii)H. nanaexpresses several stage-specific immunogens through its development in the mouse host.