Adduct of tyrosine and the oncogen 3-acetoxyxanthine
- 29 June 1976
- journal article
- Published by American Chemical Society (ACS) in Biochemistry
- Vol. 15 (13) , 2772-2775
- https://doi.org/10.1021/bi00658a010
Abstract
A major product of the reaction of L-tyrosine (I) with the activated oncogen 3-acetoxyxanthine (II) at neutral pH has been characterized as 8-xanthinyl-4'-O-tyrosine (III). A similar product is formed with tyrosylglycine. Another major product was the hydantoin of tyrosine. 8-Xanthinyl-4'-O-tyrosine is hydrolyzed in acid to yield tyrosine and uric acid but is stable in base. The synthesis of 8-phenoxyxanthine is also described. A metabolite identical with III in several chromatographic systems was found in the urine of two rats after administration of radioactive 3-hydroxyxanthine. This represented about 0.05% of the urinary radioactivity.Keywords
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