Suppressive Effect of Antibodies to Immune Response Gene Products on the Development of Low-Dose Streptozotocin-induced Diabetes
Open Access
- 1 September 1983
- journal article
- Published by American Diabetes Association in Diabetes
- Vol. 32 (9) , 869-871
- https://doi.org/10.2337/diab.32.9.869
Abstract
Low-dose streptozotocin-induced diabetes in mice serves as a model of type Idiabetes. Suppression of the development of diabetes (hyperglycemia) in C3H/ He mice was achieved with in vivo administration of antibody reactive to Ir-gene products before streptozo-tocin treatment. A persistent effect was reached with two monoclonal antibodies directed against l-Ak gene products and, surprisingly, by an allo-antiserum to I-J determinants. These results suggest a role for I-A and I-J positive T-lymphocytes and/or macrophages in B-islet cell autoimmunity.Keywords
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