Pharmacokinetics of High-Dose Meropenem in Adult Cystic Fibrosis Patients

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Abstract
Because patients with cystic fibrosis (CF) have pulmonary exacerbations secondary to multi-antibiotic-resistant Gram-negative bacilli, antibiotics, like meropenem, are often utilized. We studied the pharmacokinetics of meropenem (2 g i.v. administered every 8 h in clinically stable CF patients to determine if the recommended maximum doses could sustain adequate concentrations during the dosing interval. These pharmacokinetic data were similar to those obtained in non-CF populations. Using this regimen, concentrations of meropenem exceed the susceptibility breakpoint (4 µg/ml) for 50% of the dosing interval, and therefore provide optimization of the pharmacodynamic profile of the compound.

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