Plasma renin activity and urine β2-microglobulin during and after cardiopulmonary bypass: pulsatile vs non-pulsatile perfusion

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Abstract
Fourteen patients with normal preoperative renal function underwent aortocoronary bypass graft using cardiopulmonary bypass (CPB) with pulsatile (P; n = 7) or non pulsatile (NP; n = 7) perfusion. In the two groups prebypass values of plasma renin activity (PRA) and urine β2-microglobulin (β2-M) were within normal limits. PRA increased significantly during CPB and the first 6 h after CPB only in the non-pulsatile group. In both groups, the urine β2-M level increased significantly during and after CPB; however, there was no significant difference in urine β2-M levels between the two groups. Also, the amount of β2-M excreted in urines per unit of time increased significantly in both groups during and after CPB; there was no significant difference between the two groups.