Synthesis of oxytocin using the solid phase technique

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Abstract
This communication reports the synthesis of oxytocin using the Merrifield solid phase technique. For the synthesis both the o-nitrophenyl sulfenyl and t-butyloxycarbonyl blocking groups were used for masking the amino function. The oxytocin precursor obtained gave the same yield of hormone when subjected to the usual procedures as that obtained from a nonapeptide synthesized by conventional methods.

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