Systematic Discovery of New Genes in the Saccharomyces cerevisiae Genome

Open Access

1 February 2003

journal article
research article
Published by Cold Spring Harbor Laboratory in Genome Research

Vol. 13 (2) , 264-271
https://doi.org/10.1101/gr.232903

Abstract

We used genome-wide comparative analysis of predicted protein sequences to identify many novel small genes, named smORFs forsmall open readingframes, within the budding yeast genome. Further analysis of 117 of these new genes showed that 84 are transcribed. We extended our analysis of one smORF conserved from yeast to human. This investigation provides an updated and comprehensive annotation of the yeast genome, validates additional concepts in the study of genomes in silico, and increases the expected numbers of coding sequences in a genome with the corresponding impact on future functional genomics and proteomics studies.

Keywords

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