Repair of DNA Double-Strand Breaks in Irradiated Yeast Cells under Nongrowth Conditions
- 1 June 1980
- journal article
- research article
- Published by JSTOR in Radiation Research
- Vol. 82 (3) , 498-510
- https://doi.org/10.2307/3575316
Abstract
In diploid yeast radiation-induced DNA double-strand breaks can be repaired under nongrowth conditions at 30.degree. C and that liquid holding recovery of colony-forming ability is accompanied by a decrease in the number of double-strand breaks per cell. The kinetics of double-strand break repair under nongrowth conditions depend on the dose applied. For the highest dose used (2400 grays) repair is completed within about 48 h. Double-strand breaks which remain unrepaired after 48 h are irreparable under nongrowth conditions. The linear relationship between the initial number of double-strand breaks and dose is converted into a quadratic function of irreparable double-strand breaks with and dose during liquid holding treatment of cells.This publication has 2 references indexed in Scilit:
- The production and repair of double strand breaks in cells from normal humans and from patients with ataxia telangiectasiaBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1977
- The repair of double-strand breaks in the nuclear DNA of Saccharomyces cerevisiae and its genetic controlMolecular Genetics and Genomics, 1976