Oxidative stress studied in intact mammalian cells
- 17 December 1985
- journal article
- Published by The Royal Society in Philosophical Transactions of the Royal Society of London. B, Biological Sciences
- Vol. 311 (1152) , 673-677
- https://doi.org/10.1098/rstb.1985.0172
Abstract
Exposure of isolated rat hepatocytes to toxic doses of menadione (2-methyl-1,4- naphthoquinone) results in enhanced formation of active oxygen species, depletion of cellular glutathione and protein thiols, and perturbation of intracellular calcium ion homeostasis. An increase in cytosolic Ca 2+ concentration, resulting from inhibition of the plasma membrane Ca 2+ translocase by menadione metabolism, appears to be critically involved in the development of cytotoxicity.Keywords
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