Alterations in β1‐ and β2‐Adrenergic Receptor Density in the Cerebellum of Aging Rats
- 1 July 1980
- journal article
- Published by Wiley in Journal of Neurochemistry
- Vol. 35 (1) , 273-275
- https://doi.org/10.1111/j.1471-4159.1980.tb12517.x
Abstract
The densities of β1, and β2-adrenergic receptors were determined in homogenates of cerebral cortex and cerebellum of rats between 3 and 14 mo of age. No change in either receptor population occurred in the cortex during this period. In the cerebellum, a 20–25% decrease in the density of β2, receptors and a 3509% increase in the density of β1, receptors occurred. The increase in β1 receptors in the cerebellum may be the result of a decrease in the function of the noradrenergic projections from the locus coeruleus which synapse on cerebellar Purkinje cells.Keywords
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