CORRELATION BETWEEN DEFICIENCY OF IMMUNOGLOBULIN SUBCLASS G3 AND Gm ALLOTYPE

Publisher Website
Google Scholar
Abstract
Gm allotypes were investigated in 63 Swedes: 46 females and 17 males, in whom serum IgG3 was below 0.35 g/l. Both monoclonal antibodies and polyclonal antisera were used for the quantification. Concentrations of the other IgG subclasses were within the age-related normal ranges. The distribution of the IgG1 genetic markers Glm(a,x,f) differed markedly from that observed in normal Swedes (p < 0.001). Thus Gl m(a) was present in 60 subjects as compared to an expected 36, and phenotype Gl m(-f) in 34 subjects as against an expected 8. The mean IgG3 concentration was numerically lower in the Gl m(-f) group than in the Gl m(+f) cohort, and individuals with IgG3 levels 0.10 g/l were more frequent in the Gl m(-f) group. Among Caucasians, G3m8 is in linkage disequilibrium with G lm2 and our interpretation is that the haplotype Gl ma:ax G2m−n G3m8 is markedly increased in individuals with IgG3 deficiency.