Antifungal Properties of the Polymyxins

Publisher Website
Google Scholar
Abstract
Fungicidal activity of polymyxins B and E against Candida albicans in the presence of serum was greater than that of benzoic, salicylic and undecylenic acids and Asterol, and [2-dimethylamino-6-beta-diethylaminoethoxy)-benzo thiazole HCL] equal to that of G-4 [bis-(2-hydroxy-5-chlorophenyl)- methane]. Activity of polymyxins B and E was greater than that of benzoic and salicylic acids against Trichophyton mentagrophytes, but less than that of undecylenic acid, Asterol and G-4. Against T. purpureum polymyxin E was more active than the organic acids, but less active than Asterol and G-4. Polymyxin E was also more effective than benzoic and salicylic acids against Microsporum audouini, equal to undecylenic acid but somewhat less active than Asterol and G-4. Polymyxins B and E were the most active of the substances tested against Debaryomyces neoformans in the presence of serum. Activity of the polymyxins was not significantly inhibited by serum; benzoic and salicylic acids were only slightly affected, while undecylenic acid and G-4 were markedly antagonized. Clinical trial of the topical and systemic efficacy of polymyxins B or E in mycotic infections is suggested.

This publication has 0 references indexed in Scilit: