Comparative activity of azithromycin against clinical isolates of mycobacteria

Open Access

1 September 1996

journal article
research article
Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy

Vol. 38 (3) , 539-542
https://doi.org/10.1093/jac/38.3.539

Abstract

Azithromycin exhibited in-vitro activity against 20 clinical isolates of Mycobacterium avium complex for which the MIG₉₀ was 32 mg/L and 22 clinical isolates of other mycobacteria but showed no activity against 20 isolates of Mycobacterium tuberculosis (MIG₉₀ > 128 mg/L) nor against the single isolate of Mycobacterium marinum tested (MIC 128 mg/L). These results suggest that the drug may prove useful for the prophylaxis and treatment of infections due to non-tuberculous mycobacteria, including M. avium complex in patients with AIDS.

Keywords

TREATMENT
PROPHYLAXIS
TUBERCULOSIS
MIC
AZITHROMYCIN
MYCOBACTERIA
CLINICAL ISOLATES
TUBERCULOUS
MARINUM
MIG90

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