New Insights into Biliverdin Reductase Functions: Linking Heme Metabolism to Cell Signaling
- 1 December 2005
- journal article
- review article
- Published by American Physiological Society in Physiology
- Vol. 20 (6) , 382-389
- https://doi.org/10.1152/physiol.00029.2005
Abstract
Biliverdin reductase (BVR) functions in cell signaling through three distinct tracks: a dual-specificity kinase that functions in the insulin receptor/MAPK pathways (25, 29, 51); a bzip-type transcription factor for ATF-2/CREB and HO-1 regulation (1, 25); and a reductase that catalyzes the conversion of biliverdin to bilirubin (27). These, together with the protein’s primary and secondary features, intimately link BVR to the entire spectrum of cell-signaling cascades.Keywords
This publication has 57 references indexed in Scilit:
- Role of Heme Oxygenase-1 in the Regulation of Blood Pressure and Cardiac FunctionExperimental Biology and Medicine, 2003
- Pharmacological interventions for the treatment of neonatal jaundiceSeminars in Neonatology, 2002
- Human Biliverdin Reductase Is a Leucine Zipper-like DNA-binding Protein and Functions in Transcriptional Activation of Heme Oxygenase-1 by Oxidative StressPublished by Elsevier ,2002
- The Maf transcription factors: regulators of differentiationTrends in Biochemical Sciences, 1997
- cAMP induces heme oxygenase-1 gene expression and carbon monoxide production in vascular smooth muscle.American Journal of Physiology-Heart and Circulatory Physiology, 1997
- Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and uglyAmerican Journal of Physiology-Cell Physiology, 1996
- Biliverdin Reductase Is Heat Resistant and Coexpressed with Constitutive and Heat Shock Forms of Heme Oxygenase in BrainJournal of Neurochemistry, 1993
- Multiple sequence alignment with hierarchical clusteringNucleic Acids Research, 1988
- Kinetic properties and regulation of biliverdin reductaseArchives of Biochemistry and Biophysics, 1988
- Enzymatic heme oxygenase activity in soluble extracts of the unicellular red alga, Cyanidium caldariumArchives of Biochemistry and Biophysics, 1984