Section Review: Oncologic, Endocrine & Metabolic: The new generation of thymidylate synthase inhibitors in clinical study
- 1 June 1996
- journal article
- Published by Informa Healthcare in Expert Opinion on Investigational Drugs
- Vol. 5 (6) , 719-736
- https://doi.org/10.1517/13543784.5.6.719
Abstract
No abstract availableKeywords
This publication has 31 references indexed in Scilit:
- Ligand-induced distortion of an active site in thymidylate synthase upon binding anticancerdrug 1843U89Nature Structural & Molecular Biology, 1995
- Benzoquinazoline inhibitors of thymidylate synthase: enzyme inhibitory activity and cytotoxicity of some sulfonamidobenzoylglutamate and related derivativesJournal of Medicinal Chemistry, 1993
- Design of enzyme inhibitors using iterative protein crystallographic analysisJournal of Medicinal Chemistry, 1991
- Quinazoline antifolate thymidylate synthase inhibitors: heterocyclic benzoyl ring modificationsJournal of Medicinal Chemistry, 1991
- Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C-2 positionJournal of Medicinal Chemistry, 1990
- Quinazoline-antifolate thymidylate synthase inhibitors: benzoyl ring modifications in the C2-methyl seriesJournal of Medicinal Chemistry, 1990
- Quinazoline antifolate thymidylate synthase inhibitors: 2'-Fluoro-N10-propargyl-5,8,-dideazafolic acid and derivatives with modifications in the C-2 positionJournal of Medicinal Chemistry, 1990
- Quinazoline antifolates inhibiting thymidylate synthase: 2-desamino derivatives with enhanced solubility and potencyJournal of Medicinal Chemistry, 1989
- A potent antitumour quinazoline inhibitor of thymidylate synthetase: Synthesis, biological properties and therapeutic results in micePublished by Elsevier ,1981
- Enhancement of the therapeutic effectiveness of methotrexate and protection of normal proliferating tissues with purines and pyrimidinesChemico-Biological Interactions, 1977