Cytotoxicity of a Horse Antihuman Cancer Serum for Normal and Malignant Cells In Vitro

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Abstract
By our tissue-culture techniques we have demonstrated species-specific antibodies in Björklund's horse antihuman cancer serum absorbed with human plasma. No cancer-specific lytic antibody that could not be absorbed by normal tissues was detected. Absorption studies with cancer or liver tissues removed cytolytic activity for both normal and malignant cells. If absorption was incomplete, a drop in cytotoxic activity was reflected by a delay in cell damage. When absorption was ineffective, as with skeletal muscle, brain, or plasma, lysis occurred to both normal and cancer cells. In our experiments the Sillen antiserum did not reveal a cancer-specific antibody directed against an antigen characteristic of neoplasia.

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