The Effects of Five Potassium Chloride Preparations on the Upper Gastrointestinal Mucosa in Healthy Subjects Receiving Glycopyrrolate

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Abstract
The effects on the upper gastrointestinal tract of five different preparations of KCl were compared in 90 healthy subjects treated with glycopyrrolate. The KCl preparations studied were (1) wax‐matrix KCI, (2) microencapsulated KCI, (3) liquid KCI, (4) experimental extended‐release capsules, (5) experimental extended‐release tablets, and (6) placebo. The subjects were endoscoped prior to and after seven days of dosing. Upper gastrointestinal mucosal pathology was seen with all of the potassium preparations as well as with placebo. No statistically significant differences between the various KCI groups or between KCI groups and placebo were seen. All of the lesions were superficial, except for one ulcer seen with the microencapsulated KCI. None of the subjects developed occult gastrointestinal bleeding. There were no differences in the incidence of abdominal symptoms.

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