Theophylline molecularly imprinted polymer dissociation kinetics: a novel sustained release drug dosage mechanism
- 1 December 1998
- journal article
- research article
- Published by Wiley in Journal of Molecular Recognition
- Vol. 11 (1-6) , 98-102
- https://doi.org/10.1002/(sici)1099-1352(199812)11:1/6<98::aid-jmr399>3.0.co;2-y
Abstract
The template release kinetics of theophylline molecularly imprinted polymers has been examined with a view to determining their potential as a controlled release drug dosage form. The basis for the ligand selectivity of these polymers has been shown through the demonstration of pre‐polymerization template– monomer complexation and HPLC studies of the product polymer ligand selectivities. The release kinetics shows a dependence upon template loading and pH. Small differences in release characteristics between imprinted and non‐imprinted (reference) polymers have been observed. Copyright © 1998 John Wiley & Sons, Ltd.Keywords
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