Determination of Some Quinoline Derivatives with Organic Brominating Agents

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Abstract
A titrimetric method has been developed in which the determination of some quinoline derivatives was possible. The proposed method involves the use of either, 1,3-Dibromo, 5,5-dimethylhydantoin (DBH) or N-Bromosuccinimide (NBS) as titrants. Primaquine is determined by direct titration and the end point is detected either visually using dye-stuffs as indicators or potentiometrically. Amodiaquine, chloroquine, quinine and quinidine are determined adopting the back-titration procedure. Also, an assay procedure was described for the analysis of mixture of primaquine and amodiaquine when dispensed together. The suggested methods could be applied to pharmaceutical preparation containing the studied compounds and the results obtained were compared favourably with those given with the official ones. The reaction pathways were suggested and confirmed through an analytical study of the reaction products.

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