Explaining the Poor Bacteriologic Eradication Rate of Single-Dose Ceftriaxone in Group A Streptococcal Tonsillopharyngitis: A Reverse Engineering Solution Using Pharmacodynamic Modeling

1 October 2005

journal article
Published by American Academy of Pediatrics (AAP) in Pediatrics

Vol. 116 (4) , 927-932
https://doi.org/10.1542/peds.2004-2294

Abstract

Objective. To explore pharmacokinetic factors underlying the poor bacteriologic eradication rate with a single 500-mg dose of ceftriaxone for streptococcal tonsillopharyngitis and to identify the minimum ceftriaxone dose required for effective treatment.

Keywords

This publication has 22 references indexed in Scilit:

Practice Guidelines for the Diagnosis and Management of Group A Streptococcal Pharyngitis
Clinical Infectious Diseases, 2002
A Comparison of Group A Streptococci from Invasive and Uncomplicated Infections: Are Virulent Clones Responsible for Serious Streptococcal Infections?
The Journal of Infectious Diseases, 2002
Group A Streptococcal Tonsillopharyngitis: Cost-Effective Diagnosis and Treatment
Annals of Emergency Medicine, 1995
Immediate vs. delayed treatment of Group A beta-hemolytic streptococcal pharyngitis with penicillin V
The Pediatric Infectious Disease Journal, 1991
Clinical Pharmacokinetics of Ceftriaxone
Clinical Pharmacokinetics, 1989
Severe Group A Streptococcal Infections Associated with a Toxic Shock-like Syndrome and Scarlet Fever Toxin A
New England Journal of Medicine, 1989
Comparison of oral cephalosporins with penicillin therapy for Group A streptococcal pharyngitis
The Pediatric Infectious Disease Journal, 1986
Association of penicillin tolerance with failure to eradicate group A streptococci from patients with pharyngitis
The Journal of Pediatrics, 1985
Bayesian Individualization of Pharmacokinetics: Simple Implementation and Comparison with Non-Bayesian Methods
Journal of Pharmaceutical Sciences, 1982
A program package for simulation and parameter estimation in pharmacokinetic systems
Computer Programs in Biomedicine, 1979