Acceleration of Hypertension and Development of Stroke in the Spontaneously Hypertensive Rat by Unilateral Ureteral Obstruction

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Abstract
Unilateral ureteral obstruction (UUO) in 6 wk old male spontaneously hypertensive rats (6-w-SHR) accelerated the elevation of blood pressure and developed stroke with high frequency from 3 wk after operation; UUO had no effect in 20 wk old SHR or 6 wk old normotensive Wistar Kyoto rats. Urinary protein excretion and plasma urea and renin concentrations in 6-w-SHR began to increase 2 wk after UUO. Removal of the obstructed kidney in 6-w-SHR 1 wk after UUO prevented the acceleration of hypertension; the same treatment 2 wk after operation did not. In the ureter-obstructed kidneys of 6-w-SHR, hydronephrotic atrophy was observed 1 wk after operation; in the opposite kidneys hypertensive vascular lesions were manifested from the 2nd wk. Regarding reversibility of the hypertensive process, the obstructed kidney is apparently more important in the early postoperative stages and the contralateral kidney is more important later.