Effects of chronic administration of (+)‐amphetamine on maze performance of the rat

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Abstract
. The influence of (+)‐amphetamine, given 1 min after each training session, on the performance of 124 rats in a Lashley III maze was measured every 48 hr. . The first three injections of the drug significantly improved the learning ability of naive rats. . With prolonged treatment, (+)‐amphetamine strongly impaired the maze performance of these rats. . The chronic administration of (+)‐amphetamine to previously trained rats produced the same adverse effect. . Amylobarbitone sodium given to previously trained rats 30 min before the training sessions completely blocked the adverse effect of (+)‐amphetamine. . (+)‐Amphetamine did not produce impairment of performance when given chronically 30 min before training sessions, to previously trained rats.