Experimental production of hemorrhagic shock in the rat

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Abstract
Hypotensive shock was produced in albino rats by removal of blood and maintenance of the blood pressure at 30 or 40 mm Hg until the spontaneous 'take-back' of blood reached a definite proportion (usually 40%) of the maximum blood loss. The rest of the blood was then infused. Controlled removal and infusion of the blood were accomplished by means of a special apparatus, which is described. While the degree and duration of hypotension are the most critical conditions in determining the severity of shock and the probability of survival, other conditions such as a high environmental temperature, a fasted state, and lack of previous exercise also lessen the capacity of the rat to withstand the stress of hypotension. The standardized method for the production of hypovolemic shock in the rat is useful in quantitative evaluation of the influence of various physical and chemical agents in the production and treatment of shock.

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