Antihepatotoxic Actions of Flavonolignans fromSilybum marianumFruits

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Abstract
The antihepatatoxic effects of flavonolignans and related constituents from Silybum marianum were examined using carbon tetrachloride- and galactosamine-induced cytotoxicity in primary cultured rat hepatocytes as model systems. Remarkable inhibitory actions were observed with silandrin, 3-deoxysilychristin, silybin and silymonin in carbon tetrachloride-treated cultures, and silydianin and silymonin were effective in preventing galactosamine-produced cell lesions. Possible structure-activity relationships are discussed. 1 Part 16 in the Tohoku University series on Liver-protective drugs