SUPPRESSOR MECHANISMS IN NEONATALLY ACQUIRED TOLERANCE TO A GROSS VIRUS-INDUCED LYMPHOMA IN RATS

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Abstract
Tolerance to a highly immunogenic Gross virus induced tumor in Wistar/Furth rats (C58NT)D was produced by neonatal infection of the rats with the virus. These rats failed to reject the tumors when challenged 8 wk after virus inoculation and mount the appropriate cell mediated immune response to the tumor. The mechanisms involved were studied in vivo by adoptive transfer into sublethally irradiated rats of tumor cells mixed with spleen cells and/or sera from normal, tolerant or tumor immune rats, and in vitro by a 51Cr release assay involving similar mixtures. The results indicate the presence of a suppression mechanism which is sensitive to irradiation and abolished by trypsinization. Weak blocking factors can also be detected in serum. An interpretation in terms of the release of virion proteins from infected cells is proposed, although participation of suppressor lymphocytes was not excluded.

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