Synthesis of 3-Benzoylcyclohexanone, A key Intermediate for the Synthesis of Ketoprofen
- 1 January 1994
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 24 (1) , 77-83
- https://doi.org/10.1080/00397919408012628
Abstract
A simple and convenient synthesis of 3-benzoylcyclohexanone, a ketoprofen precursor, is proposed. It consists of the preparation of 5-trimethylsilyl-3-cyclohexenone via disilylation of anisole followed by hydrolysis and subsequent regiospecific benzoylation and hydrogenation.Keywords
This publication has 4 references indexed in Scilit:
- Unusual Electrophilic Substitution in the Aromatic Series via Organosilicon IntermediatesSynlett, 1993
- Tetrahedron report number 205Tetrahedron, 1986
- Reactivite de lithiens derives d'ethers de la cyanhydrine du benzaldehyde vis-a-vis d'α-enones cycliquesTetrahedron, 1984
- Synthese de nouveaux derives silicies cycliques fonctionnelsJournal of Organometallic Chemistry, 1976