Errors in calculated oncotic pressure of dog plasma

Publisher Website
Google Scholar
Abstract
Several equations to calculate plasma oncotic pressure (.pi.) from the total protein concentration (C) were previously described. These equations were derived empirically from samples with a wide range of C obtained by diluting or concentrating normal plasma samples. To test these equations over a range of naturally occurring C, C and .pi. of plasma samples from 40 dogs were measured. C ranged from 5.3-8.7 g/dl and averaged 6.5 .+-. 0.1, and .pi. averaged 17.9 .+-. 0.3 mmHg. A regression equation was given. The value of .pi. increased with C much less than predicted with the commonly used equations. The albumin-to-globulin concentration ratios (A/G), determined in 27 of the dogs, decreased with increasing C (A/G = 1.56-0.128 C, r = 0.62). The lower A/G at the higher C could cause the lower than predicted increase .pi. with C, because the equations were developed from data in which A/G was constant.

This publication has 1 reference indexed in Scilit: