Substance P‐ and tyrosine hydroxylase‐ containing neurom in the human dorsal motor nucleus of the vagus nerve

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Abstract
The aim of this study was to provide a comprehensive account of the topography, morphology, and frequencies of the substance P‐ and tyrosine hydroxylase‐containing neurons in the human dorsal motor nucleus of the vagus nerve. The morphology of immunoreactive neurons was studied and llie varialions of Lhe cell distrihulions were presented hy three‐dimensional Computer reconstructions. Three types of substance P‐like immunoreactive neurons were identified. They were predominantly located in the dorsointermediate, centrointermediate, caudointermediate, and caudal division of the dorsal motor nucleus of the vagus nerve. The morphology of substance P‐like immunoreactive neurons varied according to the subnuclei in which they were found. Three types oftyrosine hydroxylase‐like immunoreactive neurons were identified, mainly in the periphery ofthe dorsal motor nucleus ofthe vagus nerve, including the medial fringe, ventrointermediate, and dorsointermediate subnuclei of the 10. Many cells throughout the ventrointermediate subnucleus of the dorsal motor nucleus of the vagus nerve are seen ventrally to intermingle with the tyrosine hydroxylase neurons of the intermediate reticular zone. Computer reconstructions provided a three‐dimensional view ofthe positions of substance P‐ and tyrosine hydroxylase‐like immunoreactive neurons within the subdivisions ofthe dorsal motor nucleus of the vagus nerve. The uneven distribution of substance P‐ and tyrosine hydroxylase‐like immunoreaetive neurons within the subdivisions suggests an involvement of these substances in some, but not all, autonornic functions of the dorsal motor nucleus of the vagus nerve.

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