Lymphocytes alloantigens associated with X-chromosome-linked immune response genes.

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Abstract
A new polymorphic alloantigen system controlled by loci on the X-chromosome was identified by using antisera from F1 hybrid mice differing in their X-chromosome. These alloantigens are associated with the X-linked immune response genes controlling the immune response to the so-called thymus independent antigens such as type III pneumococcal polysaccharide, poly(I).cntdot.poly(C), and denatured DNA. They also show association with the histocompatibility locus present on the X-chromosome. They were mainly detected on a not yet characterized thymus-derived lymphocyte subpopulation. A certain similarity with the major histocompatibility complex of the mouse supports the possibility of additional I-like regions besides the I region of the histocompatibility-2 complex.