Adrenal Factors in Hypertension

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Abstract
The relation of adrenal function to hypertension in man is discussed. It is pointed out that hypertension accompanying hyperaldosteronism may recur after removal of the tumor and correction of the electrolyte abnormality. The complex relationship between blood pressure, excretion of sodium loads, total body sodium and aldosterone excretion is emphasized. Results following bilateral adrenalectomy in man indicate a permissive role for the adrenal cortex; this is further supported by the occasional clinical observation that certain patients with Addison's disease who have an unusual pressor response to substitution therapy have had a prior hypertension or a prominent family history of this disease.