PROGRESSION AND PROGNOSIS IN PARKINSONʼS DISEASE

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Abstract
Most patients with Parkinson''s disease have some steady progression of the symptoms and it is unusual to have the disease remain in a fixed state for many years. The degree of progression varies tremendously from patient to patient and the prognosis is, therefore, variable as well. In some patients who have unilateral disease, progression is exceedingly slow and prognosis is good. in others who within the first year develop bilateral signs, particularly with akinesia, progression is usually rapid and the prognosis is poor. Certain clinical findings have been related to these variables. No definitive pattern can be established at the present time, for our knowledge of the mechanism of these differences in progression is not understood.

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