THE METABOLIC RATE AND THYROID SIZE OF CHICKS FROM DAMS WITH ALTERED METABOLISM1
- 1 October 1949
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 45 (4) , 396-402
- https://doi.org/10.1210/endo-45-4-396
Abstract
The effect of the thyroid hormone and synthetic thyroxine or thyroprotein and goiterogenic substances, such as thiouracil, on the metabolic rate and thyroid size of experimental animals has been well established. Relatively little information is available, however, on the effect of hyperthyroidism or hypothyroidism of the dam on the metabolic rate of her progeny. Hens fed a ration containing thyroprotein have been shown to produce chicks with enlarged or goiterous thyroid glands (Wheeler and Hoffman, 1948a, and McCartney and Shaffner, 1949). Chicks with goiterous thyroids have also been shown by Andrews and Schnetzler (1945) to be produced by females fed thiouracil in the ration. Since the chicks from thryoprotein-fed hens had a prolonged incubation period, a significantly greater thyroid size, and a lowered heart rate, Wheeler and Hoffman (1948a) concluded that they were hypothyroid. Assay of chick thyroidal activity, as determined by the closed-vessel technique of Smith et al. (1947),Keywords
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