A STUDY OF THE HEREDITARY NATURE OF GOUT; A REPORT OF TWO FAMILIES

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Abstract
The families of 2 gouty individuals have been systematically studied. Each member was questioned and examined for evidence of gout; in most cases blood was quantitatively analyzed for uric acid, and in some instances joints were studied roentgeno-graphically. 7 of the 8 adult [male] members of these 2 families have hyperuricemia and 5 have clinical gout. In 1 family the father and all 3 sons have gout; in the other family a gouty father has 2 sons who have hyperuricemia but no other manifestation of gout. None of the [female][female] in these 2 families have any evidence of this disease. Case histories of the 5 men with gout are presented. This study indicates the importance of investigating relatives of gouty patients for the presence of this disease. Some of the problems of the hereditary nature of gout are discussed.
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