Epigenetic Regulation of Hematopoietic Stem Cell Self-Renewal by Polycomb Group Genes
- 1 May 2005
- journal article
- review article
- Published by Springer Nature in International Journal of Hematology
- Vol. 81 (4) , 294-300
- https://doi.org/10.1532/ijh97.05011
Abstract
Polycomb group (PcG) genes are involved in the maintenance of cellular memory through epigenetic chromatin modifications. Recent studies have implicated a role for PcG genes in the self-renewal of hematopoietic stem cells (HSCs), a process in which cellular memory is maintained through cell division. Among the PcG genes, Bmi-1 plays a central role in the inheritance of stemness, and its forced expression promotes HSC self-renewal. These findings highlight the importance of epigenetic regulation in HSC self-renewal and identify PcG genes as potential targets for therapeutic HSC manipulation.Keywords
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