PEPTIDE SEGMENT COUPLING IN AQUEOUS MEDIUM: SILVER ION ACTIVATION OF THE THIOLCARBOXYL GROUP
- 1 February 1981
- journal article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 17 (2) , 273-274
- https://doi.org/10.1111/j.1399-3011.1981.tb01992.x
Abstract
The use of the thiolcarboxyl function for the assemblage of deblocked peptide segments in aqueous medium has been investigated. The C-terminal thiolcarboxyl peptide Ac-Tyr-Arg-Arg-Glu-Arg-Gly-SH (2a) has been synthesized by the solid-phase method. The silver compound of peptide 2a was coupled to H-Phe-Ala-Glu-Gly-OH in 50% aqueous dimethylformamide to give a 40% yield of Ac-Tyr-Arg-Arg-Glu-Arg-Gly-Phe-Ala-Glu-Gly-OH.Keywords
This publication has 5 references indexed in Scilit:
- SYNTHESIS AND ANALGESIC ACTIVITY OF HUMAN β-ENDORPHIN ANALOGS SUBSTITUTED AT POSITIONS 17, 18, OR 19International Journal of Peptide and Protein Research, 2009
- An improved polystyrene support for solid phase peptide synthesisThe Journal of Organic Chemistry, 1976
- Solid Phase Peptide Synthesis. I. The Synthesis of a TetrapeptideJournal of the American Chemical Society, 1963
- Notes- Synthesis of p-Benzoylmandelic Acid.The Journal of Organic Chemistry, 1961
- Über Aminothiosäuren II. Mitteil.: S‐Analoge einiger α‐AminosäurenEuropean Journal of Inorganic Chemistry, 1954