Effect of an anti-ulcer agent, 2'-carboxymethoxy-4,4'-bis(3-methyl-2-butenyloxy) chalcone (SU-88), on the biosynthesis of gastric sulfated mucosubstances in restrained and water-immersed rats.

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Abstract
2''-Carboxymethoxy-4,4''-bis(3-methyl-2-butenyloxy) chalcone (SU-88) [from Sophora subprostrata] has an antiulcer effect which increases the resistant factors of the gastric mucosa. To clarify the mechanism of the action of SU-88, the biosynthesis of gastric sulfated mucosubstances (SMS) in vivo and in vitro was investigated in rats with gastric erosion induced by restraint and water-immersion. The incorporation of 35S-sulfate into gastric SMS was significantly reduced 18 h after the onset of stress. Pretreatment with Su-88 (500 mg/kg, p.o. [orally], x 10 days) prevented a reduction in the incorporation of 35S-sulfate due to stress when 35S-sulfate was administered in vivo. The incorporating activity of 35S-sulfate into the SMS in the isolated rat gastric mucosa with erosion was significantly increased 12 h after the onst of stress, as compared with that of the control group in vitro. The incorporation of 35S-sulfate into the SMS was still further increased by the oral administration of SU-88. The mode of action of SU-88 on the biosynthesis of SMS was discussed.

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