A Murine Renal Cell Carcinoma

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Abstract
A renal cell carcinoma animal model was developed and characterized in BALB/cCr mice. Although transplantable by different routes (intramuscular, intraperitoneal, intravenous, subcutaneous), it was most effective intrarenally. The tumor was transferred with as few as 1000 live cells, but not by a tenfold concentration of a cell-free tumor extract. The renal tumor increased hematocrit and erythropoietin, but did not consistently alter other serum chemistries. Tumor growth was enhanced by testosterone or diethylstilbestrol but was unaffected by a progestational agent. The growth of the tumor was reproducible both in terms of the size and weight of the primary lesion, and in terms of the distribution and number of metastatic lesions. Survival interval and death from tumor were also consistent and reproducible.

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