Immunoassayable Beta-Endorphin Level in the Plasma and CSF of Heroin Addicted and Normal Subjects Before and After Electroacupuncture

Abstract
The present study was undertaken to evaluate if plasma or CSF β-endorphin level can be induced to rise during the treatment of heroin addiction by electroacupuncture. Based on the examination of 30 addicts, we obtained no evidence indicating an increase of β-endorphin level in either the plasma or the CSF after 30 min of acupuncture. In spite of this, the majority of the addicts experienced a reduction of withdrawal symptoms during treatment. Since electroacupuncture may only induce a highly localized secretion of β-endorphin in the brain, our results cannot unequivocally exclude the possibility that this peptide is involved in mediating the action of acupuncture.

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