Spontaneous release of Fc receptor‐like material from human lymphoblastoid cell lines

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Abstract
In the culture medium of some human lymphoblastoid cell lines material is released with the following properties: (a) hemagglutination reaction of IgG‐sensitized erythrocytes; (b) enhancement of precipitation of DNA‐anti‐DNA complexes; (c) inhibition of binding of Clq to immune complexes; (d) inhibition of immune complex binding to lymphocytes; (e) inhibition of antibody‐dependent lymphocytotoxicity The material is not identical with Clq or rheumatoid factor, it is heat resistant (30 min at 56 °C); the molecular weight is about 100 000 daltons and it is capable of inhibiting antibody production in vitro It is suggested that this material consists of Fc receptors spontaneously shed from lymphocyte membranes.