The Determination of the Relative Configuration of Morphine, Levorphanol and Laevo-Phenazocine by Stereoselective Adsorbents
- 1 December 1960
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 12 (Supplement) , 228T-236T
- https://doi.org/10.1111/j.2042-7158.1960.tb10480.x
Abstract
The preparation of levorphanol, dextrorphan and morphine stereoselective adsorbents is described. These adsorbents are used to show that the laevo isomers of morphine, phenazocine and a related compound, and racemorphan and related morphinans have similar configurations; the analgesic activity of the various compounds resides substantially in these laevo isomers.Keywords
This publication has 10 references indexed in Scilit:
- THE NATURE OF THE SPECIFICITY OF ADSORPTION OF ALKYL ORANGE DYES ON SILICA GELCanadian Journal of Chemistry, 1959
- Communications- A New Potent Synthetic AnalgesicThe Journal of Organic Chemistry, 1959
- A New Series of Potent AnalgesicsJournal of Pharmacy and Pharmacology, 1957
- A Method for the Determination of the Configuration of Organic Molecules using ‘Stereo-selective Adsorbents’Nature, 1957
- 600. Configurational studies in synthetic analgesics. Part III. The configuration of (–)-phenadoxoneJournal of the Chemical Society, 1957
- 162. Configurational studies in synthetic analgesics : the synthesis of (–)-methadone fromD-(–)-alanineJournal of the Chemical Society, 1957
- On Some Physiological Actions of (+)-MorphineProceedings of the Japan Academy, 1957
- Analgesics and their Antagonists: Some Steric and Chemical ConsiderationsJournal of Pharmacy and Pharmacology, 1956
- Synthetic Analgesics: Stereochemical ConsiderationsJournal of Pharmacy and Pharmacology, 1954
- Oxy‐morphinane. (3. Mitteilung). Optisch aktive 3‐Oxy‐morphinaneHelvetica Chimica Acta, 1951