Characteristics of Complement Fixation by Aggregated IgE

Open Access
Publisher Website
Google Scholar
Abstract
Aggregated IgE fixed late components of complement (C), i.e., C3–C9, through an alternate pathway, bypassing C1, 4, and 2 whereas monomeric IgE did not. The aggregate, however, did not fix purified C3, suggesting that C3 activator system is involved in the reaction. On a weight basis, aggregated Fc had higher C-fixing activity than aggregated IgE, and aggregated F(ab′)2 was less active. The results indicated that structures essential for C fixation are present in the Fc portion of IgE molecules. A mild reduction and alkylation of IgE, which degraded structures involved in passive sensitization of monkey skin, did not affect the C-fixing properties of the protein.

This publication has 0 references indexed in Scilit: