Morphine Lowering of Self-Stimulation Thresholds: Lack of Tolerance with Long-Term Administration
- 14 January 1977
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 195 (4274) , 189-191
- https://doi.org/10.1126/science.831268
Abstract
Rats were given increasing amounts of morphine over a period of weeks in order to achieve tolerance. Doses of the drug which initially reduced the threshold for self-stimulation behavior continued to do so after long-term administration. These results demonstrate a persistent central effect of morphine which may be related to the opiate "high."This publication has 11 references indexed in Scilit:
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