The mechanism of wound repair in the skin of juvenile Atlantic salmon, Salmo salar L., following hydrocortisone implantation

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Abstract
Juvenile Atlantic salmon, Salmo salar L., were implanted with different amounts of the stress hormone hydrocortisone in cocoa butter and wounded with small surgical incisions on the ventral and dorsal surfaces. Hydrocortisone had no effect on epidermal migration which closed the wound by 8 h. Although low levels of hydrocortisone had little effect on wound healing after 3 months, high levels retarded dermal repair, particularly fibrosis and closure of the stratum compactum. Ultrastructural findings indicated that fibroblast activity was impaired. The implications for aquaculture are discussed.